Yoga therapy has proved extremely helpful for many chronic health conditions. This course covers the provision of yoga therapy for the conditions of insomnia, hypertension, stroke, cancer, pre-menstrual Syndrome, PTSD, dysmenorrhea, and menopause. We review the anatomy of systems involved, basic pathophysiology in an overview of the condition, consider personal testimonials and case studies, scientific evidence, analyse asana and pranayama for each condition, including an overview of the basic tenets and practices of trauma-sensitive yoga, and study contraindications and special considerations and modifications. This provides a good foundation for practical application of the concepts presented in class, in combination with appropriate yoga therapy protocols, during the residential practicum, which consists of role play, case study analysis, and class discussion. Medical, Ayurvedic, and subtle energy perspectives on these health challenges are addressed to guide and inform choices of therapeutic interventions. A salutogenesis perspective is studied. Case studies are presented for practical application of the concepts in class in combination with appropriate yoga therapy protocols. The course also studies the therapeutic relationship and students are expected to apply concepts learned during role plays and case study analysis. The business of yoga therapy covers aspects of taking yoga therapy into professional environments, some legal requirements, financial and administrative aspect, and professional ethics and standards. Students apply and consolidate their knowledge by writing up their experience working with volunteer clients sourced through their communities of practice during home study practicum, which comprises 27 hours of one-on-one yoga therapy with two volunteers.